It’s Collective

Knowledge, Analytics,

Formulation, and Modeling

Case Studies

Publications

1. Bagchi, S. Li, W. Plakogiannis, F. “Optimization and prediction of drug release from matrix tablets using response surface methodology and near infrared chemical imaging”. Pharm. Dev. Tech. (2011) 1-9.

2. Li, W. Woldu, A. Araba, L. Winstead, D. “Determination of swelling and release mechanisms from matrix tablets consisting of HPMC and high dose water soluble drug by near infrared chemical imaging” J. Pharm. Sci. 99 (2010) 3081 – 3088.

3. Li, W. Bagnol, L. Berman, M. Chiarella, R. A. Gerber, M. “Application of NIR in early stage formulation development. Part II. Content uniformity evaluation of low dose tablets by principle component analysis” Int. J. Pharm. 380 (2009) 49-54.

4. Bashai-Woldu, A. Li, W. Winstead, D. “Monitoring of pseudo-polymorphic conversion of a solvate API during a solvent or aqueous based fluid bed granulation by near infrared spectroscopy” Pharm. Tech. Eur. 20 (2008) 48-55.

5. Li, W. Bashai-Woldu, A. Kelly, R. Bruce, R. Rasmussen, H. Cunningham, J. Winstead, D. “Measurement of drug agglomerates in powder blending simulation samples by near infrared chemical imaging”. Int. J. Pharm. 350 (2008) 369-73.

6. Li, W. Cunningham, J. Rasmussen, HT. Winstead, D. “A qualitative method for monitoring of nucleation and granule growth in fluid bed wet granulation by reflectance near-infrared spectroscopy”. J Pharm Sci. 96 (2007) 3470-3477.

7. Li, W. Bashai-Woldu, A. Ballard, J. Johnson MC. Agresta, M. Rasmussen, HT. Hu, S. Cunningham, J. Winstead, D. “Applications of NIR in early stage formulation development. Part I. Semi-quantitative blend uniformity and content uniformity analyses by reflectance NIR without calibration models”. Int. J. Pharm. 340 (2007) 97-103.

8. Li, W. Johnson, MC. Bruce, R. Rasmussen, HT. Worosila, GD. “The effect of beam size on real-time determination of powder blend homogeneity by an online near infrared sensor”. J. Pharm. Biomed. Anal. 43 (2007) 711-717.

9. Li, W. Johnson, MC. Bruce, R. Ulrich, S. Rasmussen, HT. Worosila, GD. “Mass-balanced blending uniformity assessment of pharmaceutical powder blends by at-line near-infrared spectroscopy with a fiber-optic probe”. Int. J. Pharm. 326 (2006) 182-185.

10.Li, W. Worosila, G. Wang, W. Mascaro, T. “Determination of polymorph conversion of an active pharmaceutical ingredient in wet granulation using NIR calibration models generated from the premix blends”, J. Pharm. Sci. 94 (2005) 2800-2806

11.Li, W. Worosila, G. “Quantitation of Active Pharmaceutical Ingredients and Excipients in Powder Blends Using Designed Multivariate Calibration Models by Near Infrared Spectroscopy”, Int. J. Pharm. 295 (2005) 213-219.

12.Wang, X. Li, W. Rasmussen, H.T. “Orthogonal Method Development Using Hydrophilic Interaction Chromatography and Reversed Phase HPLC for the Determination of Pharmaceuticals and Impurities”, J. Chromatogr. A. 1083 (2005) 58-62.

13.Styslo-Zalasik, M. Li, W. “Determination of topiramate and its degradation product in liquid oral solutions by high performance liquid chromatography with a chemiluminescent nitrogen detector”, J. Pharm. Biomed. Anal. 37 (2005) 529-534.

14.Li, W. Nadig, D. Rasmussen, H. T. Patel, K. Shah, T. “Sample Preparation Optimization for Assay of Active Pharmaceutical Ingredients in Transdermal Drug Delivery System Using Experimental Designs”, J. Pharm. Biomed. Anal. 37 (2005) 493-498.

15.Li, W. “Trace analysis of residual methyl methanesulfonate, ethyl methanesulfonate and isopropyl methanesulfonate in pharmaceuticals by capillary gas chromatography with flame-ionization detection”, J. Chromatogr. A. 1046 (2004) 297-301.

16.Li, W. Rasmussen, H. T. “A Strategy for Developing and Optimizing HPLC Methods in Pharmaceutical Development Using Computer-Assisted Screening and Plackett-Burman Experimental Design”, J. Chromatogr. A. 1016 (2003) 165-180.

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